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Preparation of carbon-14 labeled hair dyes: Disperse blue 1

✍ Scribed by Bertold D. Berrang; Anita H. Lewin

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 306 KB
Volume: 38
Category: Article
ISSN: 0022-2135
DOI: 10.1002/(sici)1099-1344(199610)38:10<907::aid-jlcr909>3.0.co;2-v

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✦ Synopsis

Friedel-Crafts acylation of [U-14C]pdichlorobenzene with 3,6-dichloro hthalic anhydride in aluminum bromide melt followed by oleum cyclization afforded [U-p4C]-1 ,4,5,8-tetrachloroanthraquinone. Potassium fluoride mediated amidosulfonation followed by hydrolysis gave [U-14C]-1,4,5,8-tetraaminoanthraquinone with specific activity 39.7 rnCi/mmol in 5.6% radiochemical yield.

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Preparation of carbon-14 labeled hair dy

Preparation of carbon-14 labeled hair dyes: Nitrophenylenediamine

✍ Louise Fudala; Anita H. Lewin 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 263 KB

Nitration of N-ethoxy~arbonyl-[U-~~C]aniline with two equivalents of nitric acid in sulfuric acid afforded N-ethoxycarbonyl-2,4-dinitro-[U-l4C]aniline which was deprotected quantitatively to P,Cdinitro-[U-l4C]aniline. Selective hydrogenation provided 99.5% radiochemically pure [U-I 4C]nitrophenylene