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Preparation of ‘carba’ dipeptides bearing a basic side-chain at the C-terminus: synthesis of enantiopure Boc-d-Phe-Ψ[CH2CH2]-l-Arg(NO2)-OH and Boc-d-Phe-Ψ[CH2CH2]-d-Arg(NO2)-OH

✍ Scribed by Andrew S. Kende; Han-Qing Dong; Adam W. Mazur; Frank H. Ebetino


Book ID
104231240
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
106 KB
Volume
42
Category
Article
ISSN
0040-4039

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“Carba” peptide bond surrogates: synthes
✍ Marc Rodriguez; Annie Heitz; Jean Martinez 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 265 KB

## Abstra A synthesis of Boc-L-Leu-\r(CHz-CHz&Phe-OH and Boc-~-L~u-u~(CH~-CH~)-Q-Phe-OH from Boc-ghomo-L-leucinal, through a Horner-Emmons reaction with ethyl 2-(diethylphosphono)-3-phenylpropionate is described. Intermediate cyclisation into lactames (3S,6R)-3-benzyl6-isobutyl-piperidin-2-one and