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Preparation of Boc-Amino-Acid or Peptide Aldehydes via Reduction of Corresponding Phenyl Esters

✍ Scribed by Pavol Zlatoidsky

Publisher: John Wiley and Sons
Year: 1994
Tongue: German
Weight: 318 KB
Volume: 77
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19940770117

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✦ Synopsis

A new alternative method for the preparation of amino-acid and peptide aldehydes based on reduction of corresponding phenyl esters with lithium tri(tert-butoxy)aluminium hydride is described.

Introduction. -In a framework of synthesis of enzyme inhibitors, we studied new synthetic routes to N2-protected amino-aldehydes and peptide aldehydes.

Known methods for the preparation of Nz-protected amino-aldehydes are the reduction of corresponding methyl esters with diisobutyl aluminium hydride (AlH(i-Bu),) [I],

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