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Preparation of biologically active platelet-derived growth factor type BB from a fusion protein expressed in Escherichia

✍ Scribed by Hoppe, J.; Weich, H. A.; Eichner, W.

Book ID
126895020
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
988 KB
Volume
28
Category
Article
ISSN
0006-2960

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## Abstract Most gastrointestinal stromal tumors (GISTs) have gain‐of‐function mutations of the c‐__kit__ gene. Previously, we found 2 types of gain‐of‐function mutation of the __PDGFRA__ gene, Val^561^ to Asp and Asp^842^ to Val, in about half of GISTs without c‐__kit__ gene mutations. Although th