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Preparation of benzylphosphonates via a palladium(0)-catalyzed cross-coupling of H-phosphonate diesters with benzyl halides. Synthetic and mechanistic studies

✍ Scribed by Lavén, Gaston; Kalek, Marcin; Jezowska, Martina; Stawinski, Jacek


Book ID
119966328
Publisher
Royal Society of Chemistry
Year
2010
Tongue
English
Weight
685 KB
Volume
34
Category
Article
ISSN
1144-0546

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ChemInform Abstract: Preparation of Benz
✍ Gaston Laven; Marcin Kalek; Martina Jezowska; Jacek Stawinski 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 38 KB

## Abstract A new and efficient method for the synthesis of benzylphosphonate and benzylphosphonothioate diesters (including nucleosides), involves a palladium(0)‐catalyzed cross‐coupling between benzyl halides and H‐phosphonate or H‐phosphonothioate diesters using Pd~2~(dba)~3~(CHCl~3~) as a palla

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