Preparation of azido derivatives from amino acids and peptides by diazo transfer
✍ Scribed by Zaloom, Jeffrey; Roberts, David C.
- Book ID
- 118152003
- Publisher
- American Chemical Society
- Year
- 1981
- Tongue
- English
- Weight
- 514 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
## Abstract The diazo ketones derived from Z‐ and Boc‐protected alanine, valine, and alanyl‐alanine (1–5) were decomposed by catalytic amounts of silver benzoate/Et~3~N in the presence of polyfunctional nucleophiles such as 3‐methyl‐1,3‐butanediol, 2‐aminoethanol, carbohydrates (xylofuranose and su
## Abstract L‐Amino acids (L‐Ala, L‐Phe, L‐Val, L‐Pro) were used as a source of chirality in the diastereoselective synthesis of tetrahydroisoquinoline derivatives. The key step was the Pictet−Spengler condensation of ketoamides **4** and **10**, which proceeded under very mild conditions. L‐Ala, L