Preparation of antituberculous polyoxyethylene ethers of homogeneous structure

✍ Scribed by J.W. Cornforth; E.D. Morgan; K.T. Potts; R.J.W. Rees

• Publisher: Elsevier Science
• Year: 1973
• Tongue: French
• Weight: 879 KB
• Volume: 29
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)83411-6

✦ Synopsis

Polyoxyethylene ethers of homogeneous structure have been prepared from a macrocyclic, tetrahydric phenol ("HOC"), and from cholesterol by reaction with monofunctional derivatives of polyethylene glycols. Many practical dtfficulties had to be overcome in the preparation of these compounds. The effect on experimental tuberculosis of some of these products was compared with that of corresponding polyoxyethylene ethers produced by random polymerization. Several other surface-active compounds were prepared in an exploration of the structural requirements for chemotherapeutic activity.