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Preparation of .alpha.-trifluoromethyl esters from malonic esters

✍ Scribed by Everett, T. Stephen; Purrington, Suzanne T.; Bumgardner, Carl L.


Book ID
120592193
Publisher
American Chemical Society
Year
1984
Tongue
English
Weight
746 KB
Volume
49
Category
Article
ISSN
0022-3263

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πŸ“œ SIMILAR VOLUMES


Direct Preparation of Trifluoromethyl Ke
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Previously difficult to prepare, aliphatic and alicyclic trifluoromethylketones (e.g. 1 and 2), which are of pharmacalogic interest as potential enzyme inhibitors, can now be synthesized easily and efficiently. The one-step reaction starting with carbonic esters and trimethyl(trifluoromethyl)silane

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