An Improved Synthesis of a Galactosylate
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BjΓΆrn Holm; Johan Broddefalk; Sara Flodell; Eric Wellner; Jan Kihlberg
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Article
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2000
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Elsevier Science
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French
β 151 KB
Different protective groups for (5R)-5-hydroxy-l-lysine were investigated in silver silicate promoted glycosylations with acetobromogalactose as glycosyl donor. Best results were obtained with Fmoc-Hyl(Cbz)-OAll, which was glycosylated in 80% yield. Removal of the allyl group gave a b-d-galactosylat