Preparation of a cyclohexanone intermediate for synthesis of thromboxane antagonists
โ Scribed by Peter J. Harrison
- Book ID
- 104244556
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 193 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
An efficient route to cyclohexanone (2) is reported, providing multigram quantities of (2) in 35% overall yield from ketoacid (3).
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The synthesis and biological evaluation of a fluorescent labeled probe for the thromboxane A2 receptor is described. Since the discovery of thromboxane A2 (TXA2, 1), an unstable metabolite of the arachidonic acid cascade, 4 a variety of stable analogs, each with a modified ring system, have been pr