Preparation of a biocompatible albumin-coated ion exchange resin for bilirubin removal from the blood of jaundiced newborns
✍ Scribed by Sideman, S. ;Mor, L. ;Brandes, J. M. ;Lupovitch, S.
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 921 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0021-9304
No coin nor oath required. For personal study only.
✦ Synopsis
Removal of bilirubin by hemoperfusion with ion exchange resin partides is sug- gested to replace exchange transfusion of blood of jaundiced infants in some cases of unconjugated hyperbilirubinemia. The hemoperfusion system developed here consists of a packed bed of a macroreticular resin which is made biocompatible by a coating of a monomolecular layer of albu-min. The choice of the appropriate ionic form of the resin and the proper albumin coating and crosslinking procedure assures a high bilirubin adsorption capacity and excellent blood compatibility of the resin. The albumin coated resin removes In uifro 80-90% of the bilirubin initially present in the plasma. The results encourage in VIVO clinical studies. This paper won a student award at the annual meeting of the Society for Biomaterials at Troy, NY, May 1981.