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Preparation of [99mTc]TRODAT-1 involving a simple purification method

✍ Scribed by Gyula Tóth; Zsolt Szakonyi; Balázs Kanyó; Ferenc Fülöp; Gábor Jancsó; László Pávics

Publisher
John Wiley and Sons
Year
2003
Tongue
French
Weight
93 KB
Volume
46
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Direct preparation of the novel dopamine transporter imaging agent [^99m^Tc]TRODAT‐1 results in uncertainty concerning the labelling efficiency. Without purification of the tracer, the statistically inefficient labelling yield becomes apparent in an inadequate radiochemical purity. The aim of the present work was to improve the radiochemical purity of this tracer by including a facile, on‐the‐spot purification step in the labelling process.

Kits containing 100 μg free ligand resulted in an average labelling efficiency of 91.6% (S.D. = 5.15%, n = 32), while an average of 73.0% (S.D.= 6.76%, n = 22) was obtained for the 50 μg ligand series. Introduction of solid‐phase extraction into the preparation process allowed the quantitative removal of hydrophilic species from both series of reaction mixtures. An average radiochemical purity of 98% was achieved for the purified tracer. Copyright © 2003 John Wiley & Sons, Ltd.

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