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Preparation of 5-(cyclohexylmethyl)barbituric acid derivatives by acid-catalyzed reductive cyclohexylmethylation of barbituric acids with p-hydroxy or p-methoxybenzaldehydes

✍ Scribed by Donna M Neumann; Branko S Jursic; Kenneth L Martin

Book ID: 104250499
Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 135 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00073-4

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✦ Synopsis

A very inexpensive, simple, and high yield procedure for the preparation of valuable pharmaceutical intermediates, 5-cyclohexylmethylbarbiturates, was developed starting from either p-hydroxy or p-methoxybenzaldehyde and barbituric acid. Although the reaction sequence involves several steps, such as selecting a suitable catalyst (5% Pd C in 2% percent molar ratio) and solvent (methanol-hydrochloric acid 1:1) the preparation can be carried out in only one practical step (one-pot preparation).

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