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Preparation of (4S)-4-hydroxy-3-methyl-2-(2′-propynyl)-2-cyclopentenone by combination of enzymatic hydrolysis and chemical transformation

✍ Scribed by Hidenori Danda; Akira Maehara; Takeaki Umemura


Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
152 KB
Volume
32
Category
Article
ISSN
0040-4039

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The enzymatic kinetic resolution of (-+)-4-acetoxy122]paracyclophane by Candida cylindracea lipase was investigated in water and in a two-phase aqueous organic system. The (+)-(R)-4-hydroxy-and (+)-(S)-4-acetoxyl2,2l-paracyclophanes were isolated in excellent yields and high enantiomeric excesses. T