✦ LIBER ✦
Preparation of [3H]-labelled prostaglandin E1 by hydrogenation of prostaglandin E2 over RhCl(PPH3)3. An example of selectivity in homogeneous hydrogenation
✍ Scribed by G. K. Koch; J. W. Dalenberg
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- French
- Weight
- 169 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Labelled prostaglandin El (PGE,) (Fig. l), which is used in biochemical and biological studies, can be prepared biosynthetically from labelled dihomo-y-linolenic acid or, particularly when high specific activities are required, by catalytic hydrogenation of prostaglandin E, (PGE,) over a Pd-C-catalyst t2). The latter method, however, gives a complex mixture from which we could obtain PGE, in only 10 % yield.
We have now found that homogeneous hydrogenation of PGE, with RhCl(PPh,),-catalyt (3) leads to much better results (yields up to 50 %).
EXPERIMENTAL.