The Preparation of 2-Hydroxyethyl-2,3-dihydro-2H-1,4-benzoxazin-3(4H)-one Derivatives. -An effective strategy for the preparation of the title compounds (III), important intermediates in the synthesis of a series of novel antibacterial agents, is described. -(FRECHETTE, R. F.; BEACH,
Preparation of 3,4-dihydro-2H-1,3-benzoxazines
✍ Scribed by Jack R. Gaines; Alan W. Swanson
- Book ID
- 112122389
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1971
- Tongue
- English
- Weight
- 158 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0022-152X
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📜 SIMILAR VOLUMES
In addition to the parent compounds, nine methyl-substituted l,Mibydro-4H-3,l-benzoxazines with and without N-methyl substitution were prepared. The chain tautomer could only be detected in the case of 1,2-dihydro-2+ nitrophenyl)-4H-3,1-benzoxazine in solution. The configurational and conformational
## Abstract Seventeen __N__‐substituted 3,4‐dihydro‐2__H__‐1,3‐benzoxazines [__N__‐substituent = Et, Pr^__i__^, Bu^__t__^, CH~2~C~6~H~5~ or CH(CH~3~)C~6~H~5~] were prepared and their structures studied in the light of ^13^C chemical shifts. The γ effects caused by C(α)‐methyl or C(α)‐phenyl substit
Both enantiomers of 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2carboxylic acid 2 and 2,4-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid 3 were prepared via resolution of the corresponding racemic carboxylic acids with (R)-and (S)-1-phenylethylamine, respectively. Absolute config