Preparation of 2,3-Dihydro-1H-spiro[isoquinoline-4,4′-piperidine] via an N-Sulfonyl Pictet—Spengler Reaction.
✍ Scribed by Jian Liu; Tianying Jian; Iyassu Sebhat; Ravi Nargund
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 25 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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Diels-Alder Reactions of 5,6-Dihydro-2(1H)-pyridones. Preparation of Partially Reduced cis-Isoquinolones and cis-3,4-Disubstituted Piperidines. -Dihydropyridones (I) and (IV) undergo thermal or Lewis acid induced Diels-Alder reaction with various butadienes to give cisisoquinolone derivatives. cis-