Preparation of 2-O-Arachidonoyl-1-O-stearoyl-sn-glycerol and Other Di-O-Acyl Glycerol Derivatives

✍ Scribed by Piers R.J Gaffney; Colin B Reese

• Book ID: 104256763
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 580 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)00395-x

✦ Synopsis

R(-)-2,3-and S(+)-1,2-O-Isopropylidene-sn-glycerols (4 and 9) are converted into 2-Oarachidonoyl-1-O-stearoyl and2-O-arachidonoyl-3-O-stearoyl-sn-glycerols (2 and3, respectively); glycerol is also converted into its racemic 1,2-and its symmetrical 1,3-di-O-linoleoylderivatives (14 and 17, respectively). @19 Els Sci L In connectionwith our studieson the synthesisof phosphatidyl-D-myo-inositol 3,4,5-trisphosphate (PIP3)11, we required a synthetic source of 2-O-arachidonoyl-l-O-stearoyl-sn-glycero122, and of the enantiomeric3-O-stearoyl derivative3. Wenowreportthe synthesisof bothof theseensntiomers.