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Preparation of 2-O-(3-O-carbamoyl-α-d-mannopyranosyl)-l-gulopyranose: Synthetic study on the sugar moiety of antitumor antibiotic bleomycin

✍ Scribed by Tetsuta Oshitari; Susumu Kobayashi


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
219 KB
Volume
36
Category
Article
ISSN
0040-4039

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Synthesis of 2-O-(3-O-carbamoyl-α-d-mann
✍ Tetsuta Oshitari; Masakatsu Shibasaki; Takeshi Yoshizawa; Masahiro Tomita; Ken-i 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 892 KB

A new route to the disaccharide moiety (2-O-(3-O-carbamoyl-a-D-mannopyranosyl)-L-gulopyranose) of the antitumor agent bleomycin was develolfed. Both the L-gulose synthon 21 and the 3-O-carbamoyl-D-mannose segment 30 were prepared from D-mannose in a regioselective manner by applying stannylene aceta