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Preparation of [2-2H]-2-acetamido-2-deoxy-D-glucose by epimerization of 2-acetamido-2-deoxy-D-mannose in basic deuterium oxide; and proposal of a unifying type of mechanism for the 2-epimerization of 2-acetamido-2-deoxyhexoses

โœ Scribed by Wilmar L. Salo; Miachael Hamari; Loreta Hallcher


Book ID
108308420
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
301 KB
Volume
50
Category
Article
ISSN
0008-6215

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2-Acetamido-2-deoxy-d-gluco- and -d-mann
โœ Hans Mack; Javier Villalva Basabe; Reinhard Brossmer ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 452 KB

Sialic acids are accessible synthetically by chain extension of 2-acetamido-2deoxy-D-glucose or -D-mannose with oxaloacetate'. However, due to epimerisation at C-2 under alkaline conditions, mixtures of four products are formed, the fractionation of which is sometimes difficult. The aldehydo-2-acet