✦ LIBER ✦
Preparation of 17-amino-22-(4′-azido-3′-125iodophenacyl)-17-demethoxygeldanamycin (1): An ansamycin for photoaffinity labeling
✍ Scribed by Rodney C. Schnur; Michael L. Corman
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- French
- Weight
- 328 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
An azido‐^125^iodo‐ansamycin (1) in the geldanamycin family was prepared in two steps in one reacton vessel from 17‐amino‐22‐(4′‐aminophenacyl)‐17‐demethoxygeldanamycin (3). The title compound was suitable for photoaffinity labeling proteins that interacted with ansamycins. A alternative synthesis is reported for preparation of unlabeled title compound in order to afford practical amounts of (1) for conventional biochemical studies.