𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Preparation of [131I]lipiodol as a hepatoma therapeutic agent

✍ Scribed by Jiunn-Guang Lo; Ai-Yih Wang; Yuan-Yaw Wei; Wing-Yiu Lui; Chin-Wen Chi; Wing-Kai Chan

Publisher
Elsevier Science
Year
1992
Weight
435 KB
Volume
43
Category
Article
ISSN
0883-2889

No coin nor oath required. For personal study only.

✦ Synopsis

An isotopic exchange method was used to label lipiodol with 131I. The labelling efficiency was > 92.5%, and the radiochemical purity of [131I]lipiodol was above 98% as determined by ITLC. The influencing factors e.g. the heating temperature, reaction time, pH and storage conditions were studied and the optimum conditions were determined. In a pilot study injecting [131I]lipiodol for the treatment of hepatoma, about 70% of hepatoma patients had a response to the treatment with a reduction of alpha-fetoprotein and decrease of hepatoma sizes. The overall median survival was 9 months (range 2-17 months).

📜 SIMILAR VOLUMES

Insulin-like actions of vanadium: Potent
Insulin-like actions of vanadium: Potential as a therapeutic agent
✍ Lucy Marzban; John H. McNeill 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 160 KB

## Abstract Vanadium compounds are glucose‐lowering agents that are shown to mimic/enhance most of the metabolic actions of insulin both in vitro and in vivo. Several studies have demonstrated that vanadium treatment lowers plasma glucose levels in experimental models of type 1 diabetes and enhance

Synthesis and biodistribution studies of
Synthesis and biodistribution studies of iodine-131 D-amino acid YYK peptide as a potential therapeutic agent for labeling an anti-CD20 antibody
✍ K. Sadri; M. Gandomkar; M. H. Babaei; R. Najafi; S. R. Zakavi; S. E. Sadat Ebrah 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 187 KB

## Abstract A major drawback of conventionally radioiodinated monoclonal antibodies for radioimmunotherapy is __in vivo__ dehalogenation of iodine as a result of deiodinase recognition. To solve this problem we have synthesized a YYK tri‐peptide consisting of non‐metabolizable D‐amino acids modifie