Preparation of 131I-labelled-Zn(II)-phthalocyanine

✍ Scribed by R. Franceschini; R. Mosca; G. Iori; G. Bocchiotti; E. Reddi; G. Verna; M. Fraccalvieri; C. Bonino

• Book ID: 103989517
• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 94 KB
• Volume: 45
• Category: Article
• ISSN: 0969-8043
• DOI: 10.1016/0969-8043(94)90084-1

✦ Synopsis

Ga-68 generators which employ different adsorbing materials are reported in literature (Ehrhardt and Welch, 1978; Loc'h et al., 1980).

Our generator system directly produces ionic gallium-68, such as [68Ga]gallium trichloride. A SnO, chromatographic column is employed as adsorbing system. The daughter radionuclide (68Ga) is eluted with a sterile, pyrogen-free 1.0 N HCl solution. Elution efficiency higher than 75% and 68Ge-breakthrough lower than 5 x 10m4% is routinely obtained.

The parent radionuclide ( 68Ge) was produced by cyclotron (MC40, JRC, Ispra) through a (p,2n) nuclear reaction using gallium at very high chemical purity as target material.