๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Preparation of 1-hydroxyethylidene-1,1-diphosphonic acid-intercalated layered double hydroxide and its physicochemical properties

โœ Scribed by Hirokazu Nakayama; Koji Takeshita; Mitsutomo Tsuhako

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
146 KB
Volume
92
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

โœฆ Synopsis

The intercalation of 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), which is a drug for osteoporosis, in layered double hydroxide (LDH) was examined with the goal of developing a novel drug delivery system (DDS) of HEDP. To prevent side reactions, the intercalation reaction was carried out at 0 degrees C, and at pH 4-6. The uptake of HEDP was determined as 3.5 mmol x g(-1) of LDH, and the interlayer distance increased from 7.8 to 13 A. The HEDP-release profiles into K(2)CO(3) aqueous solution and into various buffer solutions were also examined.

๐Ÿ“œ SIMILAR VOLUMES

Trivalent Cation Substitution Effect int
Trivalent Cation Substitution Effect into Layered Double Hydroxides Co2Fey Al1โˆ’y(OH)6ClยทnH2O: Study of the Local Order: Ionic Conductivity and Magnetic Properties
โœ Mourad Intissar; Rachid Segni; Christophe Payen; Jean-Pierre Besse; Fabrice Lero ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 454 KB

A series of layered double hydroxide materials of composition Co 2 Fe y Al 1ร€y (OH) 6 Cl . nH 2 O (0ryr1) was prepared via chimie douce. The crystalline parameter related to the cation to cation distance obeys the expected variation, showing that the substitution is effective over the entire range.