The structure of 6 was established as follows. The i.r. spectrum of 6 indicated the absence of hydroxyl or carbonyl groups, and the 'H-n.m.r. spectrum contained resonances for H-4,5 6 which appeared in a narrow range of chemical shifts in close l-DEOXY-3-C-METHYL-D-FRUCTOSE F J. LOPEZ APARICIO,
Preparation of 1-(azidoaryl)amido- and 1-(azidoaryl)thio-1-deoxy-d-fructose analogs
โ Scribed by James C. Goodwin
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 519 KB
- Volume
- 195
- Category
- Article
- ISSN
- 0008-6215
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Monosaccharides react non-enzymically with the N-terminal amino group and lysyl side-chain amino groups of proteins, under physiological conditions, to produce glycated proteins'. Examples of proteins known to undergo this reaction are haemoglobin, serum albumin, immunoglobulins, collagen, and lens
Amadori compounds (1-amino-1-deoxy-D-fructose derivatives) were prepared by reacting D-glucose with a series of aliphatic amino acids. These include Amadori compounds derived from glycine (1), beta-alanine (2), gamma-amino butyric acid (3), delta-aminovaleric acid (4), epsilon-amino-caproic acid (5)