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Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa

✍ Scribed by John M. Fevig; Joseph Cacciola; Joseph Buriak Jr.; Karen A. Rossi; Robert M. Knabb; Joseph M. Luettgen; Pancras C. Wong; Stephen A. Bai; Ruth R. Wexler; Patrick Y.S. Lam


Book ID
108074017
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
166 KB
Volume
16
Category
Article
ISSN
0960-894X

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A facile one step synthesis of 1,6 -dihy
✍ Nalla Ram Reddy; Ghanta Mahesh Reddy; Battu Saida Reddy; Padi Pratap Reddy πŸ“‚ Article πŸ“… 2005 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 77 KB

## Abstract A general synthetic approach to pyrazolo[4,3‐__d__]pyrimidines is reported. Aldehydes, arylideneanilines, carboxylic acids and orthoesters are used as one‐carbon units for bridging the two amino functions of 4‐amino‐1‐alkyl‐3‐propylpyrazole‐5‐carboxamides.