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Preparation, in vitro evaluation and molecular modelling of pyridinium–quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors

✍ Scribed by Komloova, Marketa; Horova, Anna; Hrabinova, Martina; Jun, Daniel; Dolezal, Martin; Vinsova, Jarmila; Kuca, Kamil; Musilek, Kamil

Book ID: 122332963
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 767 KB
Volume: 23
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2013.10.043

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Carbamate inhibitors (e.g., pyridostimine bromide) are used as a pre-exposure treatment for the prevention of organophosphorus poisoning. They work by blocking acetylcholinesterase's (AChE) native function and thus protect AChE against irreversible inhibition by organophosphorus compounds. However,