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Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing water-soluble prodrugs of paclitaxel

โœ Scribed by Maurizio Ceruti; Paola Crosasso; Paola Brusa; Silvia Arpicco; Franco Dosio; Luigi Cattel

Book ID
114163878
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
191 KB
Volume
63
Category
Article
ISSN
0168-3659

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N-acyl-urea derivatives of carbamazepine (CBZ) were synthesized through the reactions of iminostilbene with acyl-isocyanates to form N-glycyl-carbamazepine (N-Gly-CBZ, after a deprotection step) or N-acetyl-carbamazepine (N-acetyl-CBZ). N-Gly-CBZ was isolated as its water-soluble HCl salt and was de