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Preparation, characterization, andin vitro release of Ibuprofen from Al2O3/PLA/PMMA composites

✍ Scribed by Vallet-Reg�, M. ;Granado, S. ;Arcos, D. ;Gordo, M. ;Caba�as, M. V. ;Ragel, C. V. ;Salinas, A. J. ;Doadrio, A. L. ;San Rom�n, J.

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 123 KB
Volume: 39
Category: Article
ISSN: 0021-9304
DOI: 10.1002/(sici)1097-4636(19980305)39:3<423::aid-jbm11>3.0.co;2-b

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✦ Synopsis

The preparation, characterization, and in vitro release of Ibuprofen from Al 2 O 3 , poly(L-lactic acid) (PLLA), and polymethylmethacrylate (PMMA) composites are described. The release process of the anti-inflammatory drug after the immersion of composites in a buffered solution is analyzed. The rate of Ibuprofen release is related to the crystalline or amorphous form of the drug. The presence of a ceramic component, ␣-Al 2 O 3 , and a biodegradable polymer, PLLA, facilitates both Ibuprofen crystallization and drug release. In addition, these composite systems modulate the release of the stereoisomers R(-) and S(+) of the drug.

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