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Preparation, characterization, and in vitro evaluation of physostigmine-loaded poly(ortho ester) and poly(ortho ester)/poly(d,l-lactide-co-glycolide) blend microspheres fabricated by spray drying

✍ Scribed by Ling Wang; Cheng-Shu Chaw; Yi-Yan Yang; Shabbir M Moochhala; Bin Zhao; Steve Ng; Jorge Heller


Book ID
108069235
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
424 KB
Volume
25
Category
Article
ISSN
0142-9612

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Ketotifen (KT) was encapsulated into poly(D,L-lactide) (PLA) and poly(D,Llactide-co-glycolide) (PLGA 50/50) by spray-drying to investigate the use of biodegradable drug-loaded microspheres as delivery systems in the intraperitoneal cavity. Ketotifen stability was evaluated by HPLC, and degradation w