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Preparation, Characterization, and Controlled Release of Novel Nanoparticles Based on MMA/β-CD Copolymers

✍ Scribed by Yu-Yang Liu; Yu Yu; Guo-Bin Zhang; Min-Feng Tang

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
191 KB
Volume
7
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

A series of random copolymers with different β‐cyclodextrin contents were synthesized by radical copolymerization of MMA with a monovinyl β‐CD monomer. The copolymers were characterized with IR spectroscopy, elemental analysis, DSC, and TGA. Based on these copolymers, their nanoparticles were prepared by using DMF, water, and acetone as solvents. Aqueous dispersions of the nanoparticles were further obtained by dialysis against water. Zetasizer Nano‐ZS dynamic light scattering and transmission electron microscopy were employed to characterize the nanoparticles. Using camptothecin as a model drug molecule, the encapsulation efficiency and release behavior of the nanoparticles were investigated.

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