Preparation, characterization and biological studies of some novel ferrocenyl compounds

✍ Scribed by Mokhles M. Abd-Elzaher; Ibrahim A. I. Ali

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 114 KB
• Volume: 20
• Category: Article
• ISSN: 0268-2605
• DOI: 10.1002/aoc.1016

✦ Synopsis

Abstract

Reaction of ferrocene with trichloroacetimidates in the presence of TMSOTf as a catalyst gave a series of novel ferrocenyl compounds, 1–7, in good yield and by a simple method using the Friedel–Crafts reaction. Only monosubstituted ferrocenyl compounds were obtained by flash chromatography at room temperature. Attempts to separate the disubstituted ferrocenyl compounds were unsuccessful, even in the presence of excess (2:1, 3:1 or 4:1) of trichloroacetimidates. The prepared compounds have been characterized by ^1^H NMR, ^13^C NMR, IR, UV–vis and mass spectra as well as elemental analysis. The prepared compounds showed medium to good antimicrobial activity against Bacillus subtilis (+ve), Staphylococcus aureus (+ve), Candida albicans (yeast), Escherichia coli (−ve), Salmonella typhi (−ve), Aspergillus niger (fungi) and Fusarium solani (fungi). Copyright © 2005 John Wiley & Sons, Ltd.