Preparation, cation-exchange isolation and some properties of N′-methylethylenediamine-N,N,N′-triacetic acid

✍ Scribed by J.E. Powell; D.A. Johnson

• Book ID: 104146341
• Publisher: Elsevier Science
• Year: 1972
• Tongue: English
• Weight: 303 KB
• Volume: 74
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(01)86156-2

✦ Synopsis

N'-Methylethylenediamine-N,N,N'-triacetic acid has been synthesized for the first time by a classical carboxymethylation procedure (yield 71%) using cationexchange elution techniques to isolate the amino acid product from a complex reaction mixture, prior to crystallizing from an alcohol-water mixture. The product melted at 204-206~ and its I>& values appear to be about 2.5, 5.4 and 10.3. The trinegative anion of N'-metl~yletl~ylenediamine-N,N,N'-triacetic acid forms a very stable complex with cupric ion and a moderately stable complex with calcium. '. Fig. I shows the results of: (I) titrating 200 ml of 0.005 M,MEDTA with 0.1 M KOH; (2) ,titrating ,200 ml of solution made up 0.005 M in MEDTA and o.oos'M in Je Chvomatogp, 74 (1972) 269-27~.