Preparation and properties of radioactive rhenium glass microspheres intended forin vivo radioembolization therapy
✍ Scribed by Conzone, Samuel D. ;H�feli, Urs O. ;Day, Delbert E. ;Ehrhardt, Gary J.
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 250 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0021-9304
No coin nor oath required. For personal study only.
✦ Synopsis
Rhenium glass microspheres composed of metallic rhenium particles dispersed within a magnesium alumino borate glass matrix were produced by sintering ReO 2 powder and glass frit at 1050°C. The in vitro chemical durability of radioactive and nonradioactive microspheres was determined from chemical corrosion tests on microspheres immersed in phosphate-buffered saline (PBS) solution at 37°C. The dosimetric properties of these microspheres also were calculated. The rhenium glass microspheres are chemically durable in body fluids and release < 1.2% of radioactive rhenium after being immersed in PBS solution for 32 days at 37°C. Therapeutic radioactive rhenium activities can be ob-tained in < 10 h by neutron activation of these microspheres in a thermal neutron flux of 8 × 10 13 cm -2 s -1 . A 50 mg injection of radioactive rhenium glass microspheres containing 3.7 GBq of 186 Re and 8.5 GBq of 188 Re could deliver a 100 Gy dose to a cancerous liver while limiting the total body dose from rhenium dissolution in vivo to approximately 1 mGy.