Preparation and Properties of Cyclodextrin/PNIPAm Microgels

✍ Scribed by Yu-Yang Liu; Yu Yu; Wei Tian; Le Sun; Xiao-Dong Fan

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 531 KB
• Volume: 9
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200800283

✦ Synopsis

Abstract

A two‐stage precipitation polymerization in aqueous solution was used to prepare β‐cyclodextrin/poly(N‐isopropylacrylamide) (β‐CD/PNIPAm) core–shell microgels. At the first stage, core microgels with CD moieties were synthesized by precipitation copolymerization of N‐isopropylacrylamide (NIPAm) with a monovinyl β‐CD monomer. At the second stage, using the core particles as seeds, PNIPAm shell were further added onto the seeds by NIPAm polymerization. The microgels were characterized by means of Zetasizer Nano‐ZS dynamic light scattering, TEM, IR, NMR, DSC, and TGA measurements. Using paeonol as a model drug molecule, the release behaviors of the microgels were investigated. The result indicates that the core–shell microgels could respond to change in temperature. Furthermore, the release of paeonol was related to supramolecular inclusion behavior of β‐CD and temperature sensitivity of PNIPAm.

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