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Preparation and neutralization characteristics of an anti-CSF antibody

✍ Scribed by Richard K. Shadduck; Donald Metcalf

Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
520 KB
Volume
86
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Nine of ten rabbits immunized with a partially purified L‐cell CSF had demonstrable titers of anti‐CSF activity. In vitro the antibody was markedly inhibitory to both post‐endotoxin mouse sera and several mouse tissue extracts. CSF containing conditioned media prepared from a number of sources showed variable inhibition suggesting that murine CSF's may be characterized by marked antigenic differences. Human sources of CSF were also inhibited thus indicating a degree of cross‐reactivity between murine and human factors. These studies may provide the initial steps toward definition of the role of CSF in vivo.

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