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Preparation and in vivo evaluation of PEGylated spherulite formulations

✍ Scribed by Pierre Simard; Didier Hoarau; Mohamed Nabil Khalid; Emmanuelle Roux; Jean-Christophe Leroux

Book ID
116274040
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
459 KB
Volume
1715
Category
Article
ISSN
0005-2736

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This study develops protein spherulite, a new form of protein aggregation, for sustained-release applications of recombinant human interferon Ξ±-2b (rhIFN). rhIFN spherulites were prepared with different pH solutions with different kinds and concentrations of zinc salts at various incubation temperat