Preparation and HPLC application of chiral stationary phase from 4-tert-butylphenylcarbamates of cellulose and amylose immobilized onto silica gel

✍ Scribed by Jun-qing Li; Tomoyuki Ikai; Yoshio Okamoto

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 490 KB
• Volume: 32
• Category: Article
• ISSN: 1615-9306
• DOI: 10.1002/jssc.200900206

✦ Synopsis

Abstract

The 4‐tert‐butylphenylcarbamates of cellulose and amylose bearing a small amount of 3‐(triethoxysilyl)propyl residues were synthesized by a one‐pot process and efficiently immobilized onto a silica gel through intermolecular polycondensation of the triethoxysilyl groups. The obtained chiral packing materials (CPMs) were evaluated by HPLC. The polysaccharide derivatives containing about 1–2% of the 3‐(triethoxysilyl)propyl residue were efficiently immobilized with a high chiral recognition ability. The immobilized CPMs could be used with the eluents containing chloroform and tetrahydrofuran (THF), which cannot be used with the conventional coated‐type CPMs. By using these eluents, the chiral recognition for many racemates was improved.