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Preparation and Evaluation of Sustained-Release Matrix Tablets Based on Metoprolol and an Acrylic Carrier Using Injection Moulding

✍ Scribed by T. Quinten, G. P. Andrews, T. De Beer, L. Saerens, W. Bouquet, D. S. Jones, P. Hornsby, J. P. Remon, C. Vervaet

Book ID
118122455
Publisher
Springer US
Year
2012
Tongue
English
Weight
593 KB
Volume
13
Category
Article
ISSN
1530-9932

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Sustained-release and swelling character
Sustained-release and swelling characteristics of xanthan gum/ethylcellulose-based injection moulded matrix tablets: in vitro and in vivo evaluation
✍ T. Quinten; T. De Beer; F. O. Onofre; G. Mendez-Montealvo; Y. J. Wang; J. P. Rem 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 419 KB

Sustained-release matrix tablets were developed by injection moulding using metoprolol tartrate (MPT) and ethylcellulose (EC) as sustained-release agent. Dibutyl sebacate was selected as plasticiser. The influence of matrix composition, plasticiser concentration, and drug load on drug release was ev