✦ LIBER ✦

Preparation and evaluation of cationic 99Tc/99mTc dimethoxy- and diethoxy-hexanedione dioxime complexes

✍ Scribed by Z. F. Su; K. H. Linse; H. J. Steinmetz; K. Schwochau

Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 537 KB
Volume: 31
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580310108

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The new ligands 1,6‐dimethoxy‐3,4‐hexanedione dioxime (DMHD) and 1,6‐diethoxy‐3,4‐hexanedione dioxime (DEHD) were synthesized and their boron containing ^99^Tc/^99m^Tc complexes, formed by reduction of pertechnetate with BH~4~^‐^, were isolated, purified and characterized by IR/UV/VIS spectroscopy and FAB mass spectrometry. These rather stable cationic complexes differ significantly in lipophilicity as assessed by their octanol/saline partition coefficients and HPLC capacity factors. Unexpectedly the organ uptake and clearance of both complexes in mice proved to be very similar with only the uptake of ^99m^Tc‐DMHD in the kidneys being enhanced.

📜 SIMILAR VOLUMES

Study on the preparation and biological

Study on the preparation and biological evaluation of99mTc–gatifloxacin and99mTc–cefepime complexes

✍ M. A. Motaleb; M. T. El-Kolaly; A. B. Ibrahim; A. Abd El-Bary 📂 Article 📅 2011 🏛 Springer 🌐 English ⚖ 497 KB

Preparation and evaluation of99mTc(V)-DM

Preparation and evaluation of99mTc(V)-DMSA complex: Studies in medullary carcinoma of thyroid

✍ N. Ramamoorthy; Smita V. Shetye; Prakash M. Pandey; R. S. Mani; M. C. Patel; R. 📂 Article 📅 1987 🏛 Springer 🌐 English ⚖ 489 KB

Consequent to the promising results reported with 99mTc(V)-DMSA for imaging certain types of soft tissue tumors, we have developed methods to prepare this radiopharmaceutical in three ways: from freshly prepared reagents, through the use of a two component kit and use of the standard renal DMSA kit