โ Scribed by G K Sandhu; H Kaur
No coin nor oath required. For personal study only.
The diphenyllead(1V) derivatives of N-benzoyl--(glycine, m-alanine); N-formyl and N-acetyl-Lphenylalanine; N-monochloroacetyl-L-phenylalanine; N-benzoyl-(glycylglycine,DL-alanylglycine), and N-formyl-N-acetyl-and N-monochloroacetyl-(L-phenylalanylglycine) have been prepared in 1:2 molar ratio by reaction of diphenyllead dichloride with the appropriate amino-acid or dipeptide. Corresponding triphenyllead(1V) derivatives have been prepared in 1:l molar ratio by reaction of triphenyllead chloride with the thallium(1) salts of the amino-acid or the dipeptide. These complexes have been characterized by elemental analysis, IR and 'H N M R spectral studies. A polymeric hexacoordinated octahedral structure for diphenyllead(IV), and a five-coordinated distorted trigonalbipyramidal chain-type structure for triphenyllead(IV), complexes is confirmed by IR spectra. The carboxylate group acts in a bidentate manner, not as in diorgano and triorganotin(1V) complexes with these acids, where it is monadentate. The available bonding sites such as amide and peptide carbonyl (CO) and amide and peptide nitrogen atoms are not involved in bonding with lead (IV) and thus are available for bonding with the biological systems. The presence of different N- protecting groups does not affect the coordination sites around lead(1V). The triphenyllead(1V) compounds are relatively more stable than the diphenyllead(1V) compounds.
๐ SIMILAR VOLUMES
## Fourteen new diorganotin(IV) complexes of N-(5-halosalicylidene)-ฮฑ-amino acid, R 2 Sn(5-X-2-OC 6 H 3 CH NCHRCOO) (where X = Cl, Br; R = H, Me, i-Pr; R = n-Bu, Ph, Cy), were synthesized by the reactions of diorganotin halides with potassium salt of N-(5-halosalicylidene)-ฮฑ-amino acid and characte
Tri-and diphenyllead(IV) diorganophosphinodithioates, Ph,Pb(S2PRZ)4-, (n = 2 and 3; R = Me, Et, Ph) were prepared by reacting the corresponding organolead(IV) chloride with the sodium or ammonium salt of the phosphinodithioic acid. The title compounds were investigated by infrared, ' H and 3'P NMR,
## Synthesis, Characterization and Biological Activity of Diorganotin(IV) Complexes of N-(3,5-Dibromosalicylidene)-ฮฑ-amino Acid TIAN, Lai-Jin\* ,a (็ฐๆฅ่ฟ) SUN, Yu-Xi a (ๅญ็ๅธ) ZHENG, Xiao-Liang b (้ๆไบฎ) LIU, Xi-Jie c (ๅๅธๆฐ) YU, You a (ไบๆธธ) LIU, Xue-Li b (ๅ้ช่) QIAN, Bo-Chu b (้ฑไผฏๅ)