Preparation and blood compatibility of phosphorylcholine-bonded O-butyrylchitosan

✍ Scribed by Aiping Zhu; Bing Shan; Youling Yuan; Jian Shen

• Book ID: 104526576
• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 125 KB
• Volume: 52
• Category: Article
• ISSN: 0959-8103
• DOI: 10.1002/pi.1026

✦ Synopsis

Abstract

2‐Methacryloyloxyethyl phosphorylcholine (MPCE) was synthesized using phosphorus trichloride, ethylene glycol, 2‐hydroxyethyl methacrylate and triethylamine, and then used in the preparation of O‐butyrylchitosan‐bonded MPCE (MPCE–BCS) by Michael addition of MPCE to amino groups of O‐butyrylchitosan. The structures of MPCE and MPCE–BCS were characterized by FTIR and ^1^H NMR. The blood‐compatibility of MPCE–BCS was evaluated by means of blood clotting and platelet adhesion assays. The blood‐clotting assay indicated that O‐butyrylchitosan was haemocompatible. Both the blood‐clotting assay and platelet adhesion assay confirmed that MPCE–BCS had excellent antithrombogenicity.

© 2003 Society of Chemical Industry