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Preparation and biological activity of a C-terminal gastrin sequence containing a ketomethylene amino bond replacement

✍ Scribed by A.J. Douglas; S.E. Haugen; B. Rønning; B. Walker; A.K. Sandvik; H.L. Waldum; R.F. Murphy


Book ID
118397888
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
45 KB
Volume
18
Category
Article
ISSN
0167-0115

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A novel and efficient method to prepare amino acid thiohydantoins, which are required as reference standards for development of C-terminal protein sequencing, is reported. Amino acid thiohydantoins were prepared using a straightforward method involving reaction of 20 free amino acids with acetyl chl