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Preparation and biodistribution of salicylidene-aminates (schiff bases) labeled with Tc-99m

✍ Scribed by H. H. Vavouraki; E. Chiotellis; A. Varvarigou

Publisher: John Wiley and Sons
Year: 1987
Tongue: French
Weight: 550 KB
Volume: 24
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580241202

No coin nor oath required. For personal study only.

✦ Synopsis

A series of salicylidene-aminoacid Schiff bases was synthesized and labeled with Tc-99m, in neutral pH, using stannous ion as reductant. Labeling yield was greatly affected by concentration-ratios of the reactants, the optimum concentration ratio being 18.5 x 1 O-2nuno1 ligand to 0.4 x 10-2mmol SnC12 per 4 ml formulation.

Various substituents on salicylidene-phenylalanine molecule or the different amino acids used for the imine formation did not significantly influence the yield of the labeling which usually exceeded 90%. Most of the 99%c-chelates exhibited high hepatobiliary affinity, when injected intravenously in mice. Blood clearance as well as hepatic extraction rate varied with the chemical structure of the azomethine derivatives. Urinary elimination was negligible except the hydrophi lic complexes 99%c-salicylidene-isoleucine , 99%c-ealicylidene-cycloleucine and 99mTc-salicylidene-alanine which excreted to the urine as well.

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