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Preparation and antibacterial activity evaluation of rifampicin-loaded poly lactide-co-glycolide nanoparticles

✍ Scribed by Farnaz Esmaeili; Mahdi Hosseini-Nasr; Mazda Rad-Malekshahi; Nasrin Samadi; Fatemeh Atyabi; Rassoul Dinarvand

Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
533 KB
Volume
3
Category
Article
ISSN
1549-9634

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✦ Synopsis

Biodegradable polymers such as poly lactide-co-glycolides (PLGA) have been considered for the preparation of nanoparticles (NPs). In this study, rifampicin (RIF)-loaded PLGA NPs were fabricated by an emulsification/solvent diffusion method. The effect of several variables on the NPs' characteristics were evaluated, including the amount of RIF, amount of the poly vinyl alcohol as surfactant, and internal-phase volume and composition. The RIF encapsulation efficacy and the particle size distribution were optimized by varying these parameters. NPs were spherical with a relatively monodispersed size distribution. The effect of nanoencapsulation of RIF on the antibacterial activity of RIF against gram-positive and gram-negative bacteria was evaluated. It was shown that RIF NPs could considerably improve the RIF antibacterial efficacy.

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