𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Preparation and Anti-HIV Activity of N-3-Substituted Thymidine Nucleoside Analogs

✍ Scribed by Adams, David R.; Perez, Caroline; Maillard, Michel; Florent, Jean-Claude; Evers, Michel; Hénin, Yvette; Litvak, Simon; Litvak, Laura; Monneret, Claude; Grierson, David S.


Book ID
120353331
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
422 KB
Volume
40
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Synthesis and anti-HIV activity of 2′-de
✍ Qiang Wang; Yanfeng Li; Chuanjun Song; Keduo Qian; Chin-Ho Chen; Kuo-Hsiung Lee; 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 271 KB

Based on the favorable antiviral profiles of 4'-substituted nucleosides, novel 1-(2'-deoxy-2'-fluoro-4'-C-ethynyl-beta-D-arabinofuranosyl)-uracil (1a), -thymine (1b), and -cytosine (2) analogs were synthesized. Compounds 1b and 2 exhibited potent anti-HIV-1 activity with IC(50) values of 86 and 1.34