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Preparation and analysis of deuterium-labeled aspirin: Application to pharmacokinetic studies

✍ Scribed by Anders Kirstein Pedersen; Garret A. Fitzgerald


Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
519 KB
Volume
74
Category
Article
ISSN
0022-3549

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Simple and facile syntheses of highly deuterated and tritiated LiBH4, NaBH4 and KBH4 were achieved by hydrogen isotope exchange with deuterium or tritium gas at elevated temperatures. The exchange products were characterized by boron, proton and deuterium or tritium NMR spectroscopy. The extent of i