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Preoperative irradiation for unresectable rectal and rectosigmoid carcinomas

✍ Scribed by Daniel E. Dosoretz; Leonard L. Gunderson; Stephen Hedberg; Bruce Hoskins; Peter H. Blitzer; William Shipley; Alfred Cohen

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
471 KB
Volume
52
Category
Article
ISSN
0008-543X

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## BACKGROUND. Even when they are analogous in microscopic and macroscopic appearance, tumors vary in their response rates to radiotherapy. Cell culture and xenograft experiments with colorectal cell lines have demonstrated that wild-type p53 increases radiosensitivity. Hence, the authors investig