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Preoperative chemoembolization for hepatocellular carcinoma

โœ Scribed by Dr. Mario Morino; Claudio Miglietta; Maurizio Grosso; Maurizio de Giuli; Henri Bismuth

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
252 KB
Volume
53
Category
Article
ISSN
0022-4790

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โœฆ Synopsis

In a group of 396 patients who had chemoembolization for hepatocellular carcinoma (HCC) between 1984 and 1991, 67 underwent surgery (segmentaryhbsegmentary resections: 3 1 ; or transplantation: 36). Morbidity was limited to hepatic insufficiency (seven), arterial thrombosis (two), vasculitis (five), cholecystitis (two), and hepatic abscess (one). Perioperative mortality was 5.5% for transplantation and 6.7% for resection.

Histological examination of resected specimens showed a total or subtotal tumor necrosis in 58% of the cases, and a necrosis beween 50% and 80% in another 18%. Data on recurrence and long-term survival are not significant if retrospectively compared with non-chemoembolized surgically treated patients.

Chemoembolization is known to be an effective palliative treatment of HCC. Its role in the preoperative setting is substained by a 58% of total or subtotal histological necrosis. A multicentric prospective trial to evaluate the role of preoperative chemoembolization for long-term survival and recurrence of HCC is advocated.

๐Ÿ“œ SIMILAR VOLUMES

Liver transplantation for hepatocellular
Liver transplantation for hepatocellular carcinoma: Results with preoperative chemoembolization
โœ Venook, Alan P. ;Ferrell, Linda D. ;Roberts, John P. ;Emond, Jean ;Frye, John W. ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 572 KB

patients who met the following criteria-hepatic tumor unresectable because of location or inadequate liver reserve, no metastases, HBsAg negative, no tumor larger than 5 cm in diameter, and no more than three tumors-were enrolled prospectively in a protocol employing preoperative chemoembolization t

Preoperative hepatic artery chemoemboliz
Preoperative hepatic artery chemoembolization followed by orthotopic liver transplantation for hepatocellular carcinoma
โœ Harnois, Denise M. ;Steers, Jeffery ;Andrews, James C. ;Rubin, Joseph C. ;Pitot, ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 111 KB

In our experience, the primary obstacle precluding the widespread use of orthotopic liver transplantation (OLT) for definitive therapy of hepatocellular carcinoma (HCC), even for early-stage disease, is preventing tumor recurrence. Chemoembolization is an attractive strategy to minimize tumor progre