Preoperative and postoperative adjuvant combination chemotherapy for adults with high grade soft tissue sarcoma
β Scribed by Ephraim S. Casper; Jeffrey J. Gaynor; Louis B. Harrison; David M. Panicek; Steven I. Hajdu; Murray F. Brennan
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 735 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0008-543X
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## Abstract ## BACKGROUND. The authors studied a doseβintense regimen of epirubicin and ifosfamide with hypofractionated preoperative radiotherapy for highβrisk soft tissue sarcomas. The primary objective was estimation of the rate of β₯95% pathologic necrosis. ## METHODS. Twentyβfive patients wi
BACKGROUND. P-glycoprotein-mediated drug efflux has been implicated as an important mechanism of multidrug resistance (MDR) in cancer. Its role in chemotherapy resistance in soft tissue sarcoma is unclear. ## METHODS. Tumor specimens prior to and following neoadjuvant chemotherapy from 29 cases o